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Adding vitamin B12 may help reduce certain side effects, like fatigue, for some people

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In fact, serotonin manages glutamate pathways differentially across the brain: In the CNS, 5-HT exerts a very complex modulatory control over glutamate- and GABA-mediated transmission, involving many subtypes of 5-HT receptors and a large variety of effects

This therapy is not recommended for individuals who are pregnant, breastfeeding, or have certain medical conditions

The significance of iron buildup in inflamed tissue, resulting in cellular toxicity, in autoimmune and autoinflammatory illnesses associated with arthritis, such as OA, remains ambiguous [35]